Topoisomerase 2a
• Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681. PMC 1137600. PMID 7980433. • Bronner C, Hopfner R, Mousli M (2002). "Transcriptional regulation of the human topoisomerase IIalpha gene". Anticancer Research. 22 (2A): 605–612. PMID 12014628. WebJan 10, 2024 · Topoisomerase I (TOP1) relaxes both positive and negative supercoils by nicking DNA and after rotation of the broken DNA strand closes the nick. Here, the authors present the DNA free crystal ...
Topoisomerase 2a
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WebApr 7, 2015 · Topoisomerase 2A (TOP2A), the key enzyme required for generating transient double-stranded breaks in DNA topological structure, played a significant role in DNA replication and transcription and the … WebThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and …
WebApr 7, 2015 · Topoisomerase 2A (TOP2A), the key enzyme required for generating transient double-stranded breaks in DNA topological structure, played a significant role in DNA replication and transcription and the … WebAll lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human …
WebFeb 27, 2024 · Type II Topoisomerase Structure. Topoisomerase IIA in eukaryotes consists of two same monomers (A-A) whereas in prokaryotes they are formed heterotetramers … WebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. ... [16, 28], thus could probably explain the poor correlation between TOP 2A protein expression and gene amplification. Since TOP2A protein represents the ultimate expression of TOP2A as well as tumor cell ...
Type II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I topoisomerase. In this process, these enzymes change the linking number of circular DNA by ±2. … See more Type II topoisomerases increase or decrease the linking number of a DNA loop by 2 units, and it promotes chromosome disentanglement. For example, DNA gyrase, a type II topoisomerase observed in E. coli and most other See more There are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes See more Strand passage Type IIA topoisomerase operates through a "two-gate" mechanism (though this is a historical notation), … See more Small molecules that target type II topoisomerase are divided into two classes: inhibitors and poisons. Due to their frequent presence in proliferating eukaryotic cells, … See more Type IIA topoisomerases are essential in the separation of entangled daughter strands during replication. This function is believed to be … See more Type IIA Type IIA topoisomerases consist of several key motifs: • an … See more Catenation is the process by which two circular DNA strands are linked together like chain links. This occurs after DNA replication, where two single strands are catenated and can … See more
WebSep 30, 2012 · Type IIA topoisomerases (topos) control supercoiling and disentangle chromosomes by an ATP-dependent strand-passage mechanism. The structure of a full … chs brush coloradoWebHome; About. Mission Statement / Core Values; History; Membership Info; Schools. A – F; G – L; M – T; U – Z; Conferences; Classifications; Divisions; Regions ... chs bruin networkWebMay 3, 2024 · Topoisomerase 2a (Topo2a)-dependent G 2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is … describe two features of the babington plotWebMar 29, 2024 · Topoisomerase: A class of enzymes that alter the supercoiling of double-stranded DNA. (In supercoiling the DNA molecule coils up like a telephone cord, which … chsb tradingviewWebMar 19, 2024 · Top2cc was detected using the Human Topoisomerase ICE Assay Kit (Cat #TG1020-2a; Topogen). The method of DNA purification was modified by combining the … chsb teamWebFeb 28, 2024 · Topoisomerases have essential roles in transcription, DNA replication, chromatin remodelling and, as recently revealed, 3D genome organization. ... (Fig. 2a) may account for its role in activating ... describe two features of a unitary systemWebSpecifically, the interaction of NELFA with DNA topoisomerase 2a (Top2a) is essential for NELFA to activate Dux; Dux will be silenced in Top2a-deficient cells even when NELFA is overexpressed . The role of NELFA remains controversial, as other studies indicate that NELFA is a direct target of DUX rather than a driver of Dux . More data from ... chs broadcasting