WebOct 27, 2024 · pKa is an acid dissociation constant used to describe the acidity of a particular molecule. Its value is directly related to the structure of the given compound. The constant changes depending on the solvent … WebFeb 1, 1998 · This study was conducted to determine the mechanism of arachidonic acid (AA) release elicited by phenylephrine (PHE) stimulation of alpha adrenergic receptor (AR), and its modulation by cyclic adenosine 3′,5′-monophosphate (cAMP) in Rat-1 fibroblasts (R-1Fs) transfected with the alpha -1A, alpha -1B or alpha -1D AR. PHE increased AA release …
Ephedrine vs Phenylephrine - ECG Changes - Full Text View ...
WebFeb 1, 2013 · This paper described a sensitive and rapid method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC–MS/MS) for the determination of phenylephrine in human plasma. Plasma samples were pre-purified by solid-phase extraction (SPE). boats sea ray
Phenylephrine: Uses, Interactions, Mechanism of Action
WebDec 1, 2004 · Several studies also showed that hypertrophic stimuli, such as Ang II and phenylephrine, can increased intracellular cAMP levels and subsequently activate PKA, which phosphorylates cAMP response ... WebMay 19, 2024 · Phenylephrine is a decongestant that is used to treat stuffy nose and sinus congestion caused by the common cold, hay fever, or other allergies. Phenylephrine may also be used for purposes not listed in this medication guide. Related/similar drugs metoprolol, atenolol, diltiazem, dexamethasone, methylprednisolone, amiodarone, … WebJan 3, 2024 · Explanation: Using Henderson-Hasselbalch equation we can solve the [PE]/ [PEH+] ratio: pH = pKa + log [A-] / [HA] Where pH is 7.4 pKa of the phenylphrine is 5.5 [A-] is the weak base = [PE] And [HA] is the conjugate acid [PEH+] Replacing: 7.4 = 5.5 + log [PE] / [PEH+] 1.9 = log [PE] / [PEH+] 79.4 = [PE] / [PEH+] The ratio of concentrations is 79.4 climate change east lothian