WebNov 29, 2016 · Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors Further investigation of Paprotrain: Towards the … WebBiological description. Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC 50 values are 1.35 and 0.83 µM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I.
Kinesin Inhibition Kinesin Inhibitor Review & List - selleckchem
WebApr 13, 2024 · Paprotrain (PAssenger PROteins TRAnsport INhibitor), is a cell permeable, reversible, ATP-uncompetitive inhibitor of the ATPase region of KIF20A. This inhibitor is … WebView and buy high purity Paprotrain from Tocris Bioscience, a Bio-Techne brand. Reversible inhibitor of MKLP-2. Skip to main content United States - (English) Country/Region selector. Please enter your country/region. Select Preferred Language. English. 简体中文 (800) 343-7475 ... british bites menu
Paprotrain ≥98% (by NMR) VWR
WebFeb 15, 2016 · Our structure–activity relationship (SAR) study reveals the key chemical elements in the paprotrain family necessary for MKLP-2 inhibition. We have successfully identified one MKLP-2 inhibitor 9a that is more potent than paprotrain. In addition, in vitro analysis of a panel of kinesins revealed that this compound is selective for MKLP-2 ... WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition … WebFeb 15, 2016 · We have previously identified compound 1 (paprotrain) as the first selective inhibitor of MKLP-2. Herein we describe the synthesis and biological evaluation of new … british bittersweet apple cider concentrate