Lhx2 hepatic stellate cell
WebHepatic fibrosis (HF) is a chronic hepatic pathological process induced by various liver injuries, with few available therapies. Previous research studies revealed that HF is characterized by the accumulation of excess extracellular matrix in the liver, mainly overexpressed by activated hepatic stellate cells (HSC). Web22. jan 2015. · Hepatic stellate cells (HSCs) have been identified as the main fibrogenic cell type in the liver. ... Expression of HSC markers Lhx2, Lrat, Hand2, Vim and Pdgfrb and of proliferation markers Ccnb1 ...
Lhx2 hepatic stellate cell
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WebCollagen is produced in extra quantities by hepatic stellate cells induced by fibrogenic cytokines. However, progressive liver fibrosis because of repetitive and persistent injury may lead to cirrhosis, which is an irreversible condition. ... The fibrosis shows delicate enhancement in the hepatic arterial dominant phase and prominent ... WebArticle Snippet: Human hepatic stellate cell line LX-2 and HEK293T Phoenix-ampho retrovirus packaging cells (ATCC) were cultured in DMEM supplemented with 10% FBS in 5% CO2 at 37°C. Techniques: Isolation, Real-time Polymerase Chain Reaction, Expressing, Western Blot. Journal: PLoS ONE.
WebBACKGROUND AND AIM: : Activation of hepatic stellate cells (HSC) results in the transdifferentiation of the resting (quiescent) phenotype to one characterized by loss of vitamin A droplets, increased Web10. dec 2004. · LX-1 and LX-2 human HSC lines provide valuable new tools in the study of liver disease by retaining key features of HSCs and having a retinoid phenotype typical of stellate cells. Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing …
WebThe LX-2 human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid … Web03. maj 2004. · Hepatic stellate cells (HSCs) (previously known as Ito cells, lipocytes, or fat storing cells) are a major cell type responsible for liver fibrosis following their …
WebThis review article summarizes 20 years of our research on hepatic stellate cells within the framework of two collaborative research centers CRC575 and CRC974 at the Heinrich …
Weband a variety of mesenchyme-derived cell types, such as endothelial cells and hepatic stellate cells. In early stages of liver development Lhx2 is expressed in the liver … earbuds to protect hearingWeb2.1. Cell lines, reagents and antibodies. The LX-2 cell line, an immortalised human hepatic stellate cell line (Merck, Darmstadt, Germany) was cultured in high glucose DMEM … cssa scholarshipWebLHX2 (hLhx2, LH-2) protein expression summary. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... Cell type enriched (Liver - Hepatic stellate cells, Skin - Outer root sheath cells, Testis - Early spermatids, Testis - Late spermatids) IMMUNE CELLS; Immune cell ... cssa schoolHepatic stellate cells (HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes). The stellate cell is the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. css as a technical skillWeb18. okt 2024. · 2024年10月5日，美国哥伦比亚大学Robert F. Schwabe研究组发文题为Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis，通过对 … css ashamedWeb18. mar 2024. · The therapeutic approach of liver fibrosis is still an unsolved clinical problem worldwide. Notably, the accumulation of extracellular matrix (ECM) in the liver is … ear buds to remove ear waxWeb14. okt 2024. · Hepatic stellate cells (HSCs) are liver-resident myofibroblast precursors responsible for the production of collagen and maintenance of the hepatic extracellular matrix (ECM). As such, they are generally associated with fibrotic liver diseases. HSCs become "activated" in response to tissue damage or pathogen invasion, a process most … earbuds to remove wax